to Warfarin

• Stop Edoxoban
• If continuous AC needed, start Warfarin with parenteral anticoagulant at next scheduled dose

to Heparin (CI)

• Stop Edoxoban
• Start CI Heparin without a bolus at next scheduled dose

to LMWH

• Stop Edoxoban
• Start LMWH at next scheduled dose

to Dabigatran

• Stop Edoxoban
• Start Dabigatran at next scheduled dose

to Apixaban

• Stop Edoxoban
• Start Apixaban at time of next scheduled dose

to Rivaroxaban

• Stop Edoxoban
• Start Rivaroxaban <2 hours before next scheduled dose.

to Edoxoban

• N/A

*Note: Dabigatran, Rivaroxaban, Edoxaban, and Apixaban affect the INR; measuring the INR during coadministration with warfarin therapy may not be useful for determining an appropriate dose of warfarin. To minimize this effect, check INR at trough level of respective medication