FVIII & FIX Deficiencywith inhibitors Baxalta Standard t1/2HALF LIFE (hours): 4-7 hours;based on thrombin generation Plasma-derived(Activated PCC) Dosing Calculation 50-100 units/kg Q 6-12 hoursAdminister dose over ~20-30 minutesMax daily dose: 200 IU/kg Notes Warning: Contains FIX. Patients with FIX deficiency with inhibitors may experience anaphylactoid reactions with exposure to FIX products. Do not use concomitant […]
Laboratoire Francais du Fractionnement et des Biotechnologies (LFB) Standard t1/2HALF LIFE (hours): 1.4 – 1.7 hours Recombinant 2nd Gen – transgenic rabbits Cell Type: human FVII protein expressed in mammary gland of genetically engineered rabbits Indication: Treatment and control of bleeding episodes in patients >= 12 yrs old with congenital Hemophilia A or B and inhibitors to Factor […]
Novo Nordisk Standard t1/2HALF LIFE (hours): 2.6-3.1 Recombinant 2nd Gen Dosing Calculation Congenital Hemophilia A or B with Inhibitors: 90 mcg/kg every 2 hours, adjustable until hemostasis achieved. 90 mcg/kg every 3-6 hours after hemostasis is achieved for severe bleeds. Higher doses at less frequent intervals are often used 90-270 mcg/kg/dose every 4-6 hours. Acquired Hemophilia:70-90 […]
Acquired Hemophilia Baxalta Standard t1/2HALF LIFE (hours):10 hours, highly variable;Range 2.6-28.6 hrs Recombinant 2nd Gen (BDD) Porcine sequence FVIII Dosing Calculation Dosing Goals (FVIII Level): Minor bleed: 40% Major bleed: 80%Titrate as needed. Topic Dose Initial Dose 100 IU/kg Maintenance Dose 50-100 IU/kg every 6-12 hours Transfer Device Storage Refrigerate between 2 – 8°C (36 […]
