Grifols Standard t1/2HALF LIFE (hours):18 Plasma-derived *Per IHTC dosing: Half-life for all PD FIX products: ~24 hours Dosing Calculation Units = weight (kg) X % correction* X VD*Written as Whole Number (50%=50) Topic Dose IU/kg (% correction) Prophylaxis 50-100 IU/kg 2-3 x/wk Minor Bleed 40 (40%) Major Bleed 80 (80%) Topic Volume of Distribution Adult/Peds 1 […]
Biogen Extended t1/2IgG-1 Fc Domain Recombinant Fusion Protein 4th Gen HALF LIFE (hours):Adults: 87Peds:2 – 5 yrs: 66.46 – 11 yrs: 72.212 – 17 yrs: 83.6 Dosing Calculation # Units = weight (kg) X % correction* X VD*Written as Whole Number (50%=50) Topic IU/kg (% correction) Patient < 12 yrs Patient ≥ 12 yrs Prophylaxis 50 Q 7 days 100 […]
Novo Nordisk Extended t1/2Glycopegylation Recombinant HALF LIFE (hours): 3rd Gen ≤6 yrs: 69.67-12 yrs: 76.313-17 yrs: 89.4≥18 yrs: 83 Dosing Calculation Units = weight (kg) X % correction* X VD*Written as Whole Number (50%=50) Topic IU/kg (% correction) Pediatric Adult Minor Bleed (40%) (40%) Major Bleed (80%) (80%) Topic Volume of Distribution ≤6 yrs 0.66 7-12 yrs 0.62 13-17 yrs […]
CSL Bering Extended t1/2Albumin Fusion Protein Recombinant HALF LIFE (hours):Adults: 104 3rd Gen Peds:0 – 5 yrs: 906 – 11 yrs: 9312 – 17 yrs: 87 Dosing Calculation Units = weight (kg) X desired factor IX increase (IU/dL or % of normal) X VD (IU/kg per IU/dL)*Written as Whole Number (50%=50) Topic IU/kg (% correction) Patients <12 yrs Patients ≥ 12 […]
Emergent Biosolutions Standard t1/2HALF LIFE (hours): Recombinant >12 yrs: 24 3rd Gen Per IHTC dosing:Half-life for all FIX Standard t1/2 products: ~24 hours Dosing Calculation # Units = weight (kg) X % correction* X VD*Written as Whole Number (50%=50) Topic IU/kg (% correction) Pediatric Adult Prophylaxis 60-100 IU/kg 2-3 x/wk 50-100 IU/kg 2-3 x/wk Minor Bleed 40 (40%) 40 (40%) Major Bleed […]
Baxalta Standard t1/2HALF LIFE (hours): Recombinant Adults: 25.7Peds: 23.2 3rd Gen Per IHTC dosing:Half-life for all FIX Standard t1/2 products: ~24 hours Dosing Calculation # Units = weight (kg) X % correction* X VD*Written as Whole Number (50%=50) Topic IU/kg (% correction) Patients < 12 yrs Patients ≥ 12 yrs Prophylaxis 60-100 IU/kg 2-3 x/wk 50-100 IU/kg 2-3 x/wk Minor Bleed 55 […]
Pfizer Standard t1/2HALF LIFE (hours): Recombinant Adults: 18.8 + 5.4Peds: ~16 3rd Gen Per IHTC dosing:Half-life for all FIX Standard t1/2 products: ~24 hours Dosing Calculation # Units = weight (kg) X % correction* X VD *Written as Whole Number (50%=50) Topic IU/kg (% correction) Patients < 15 yrs Patients 15 ≥ yrs Prophylaxis 60-100 IU/kg 2-3 x/wk 50-100 IU/kg 2-3 x/wk […]
