Genzyme Corp. Small interfering ribonucleic acid 12 years and older with hemophilia A or hemophilia B with or without inhibitors Half Life: Dose-dependent 20 mg dose: 5.57 hours 50 mg dose: is 7.98 hours Starting Dose: 50mg SQ once every 2 months; adjust to maintain goal antithrombin activity Goal Antithrombin Activity: 15-35% Dosing Calculation Product […]
Pfizer Tissue factor pathway inhibitor (TFPI) 12 years and older with hemophilia A or hemophilia B without inhibitors Half life: ~7 – 10 days Regimen: Weekly subcutaenous injections Pregnancy Testing: Verify that females of reproductive potential are not pregnant prior to initiating Dosing Calculation Topic Dose Loading 300mg (two 150mg injections) by SQ route Maintenance One […]
Novo Nordisk Tissue factor pathway inhibitor (TFPI) 12 years and older with hemophilia A or hemophilia B with inhibitors Half Life: 1 day Dosing Calculation Topic Dose Loading 1mg/kg on day 1 Maintenance 0.2mg/kg on day 2 and thereafter Notes Labs Concizumab-mtci plasma concentration 4 weeks after initiation of treatment and prior to administration of […]
