Elective Reversal (reversal needed within days)

• Hold day of procedure
• Once-daily regimens: ½ dose day prior

Urgent Reversal (not bleeding, reversal needed within hours)

• Hold further doses
• Consider: 4-factor PCC/ aPCC*, 3-factor PCC + FFP, rVIIa

Urgent Reversal (bleeding, reversal needed immediately)

• HASHTI
• 4-factor PCC
• 3-factor PCC + FFP
• Consider rVIIa 90 mcg/kg

*The use of aPCC (FEIBA⁷⁰) may be associated with a higher risk of thrombosis compared with nonactivated PCCs¹¹⁰