Mechanism of Action

• Direct Xa inhibition

Half-Life

• 19-27 hours 

Metabolism

• 11% Renal, Biliary
• HD removal: unknown

Dosing – Adult

• VTE Prophylaxis:
  • CrCl >30: Initial: 160 mg single dose, followed by 80 mg once daily for 35 to 42 days
  • CrCl ≥15 to <30: Initial: 80 mg single dose, followed by 40 mg daily for 35 – 42 days

Dosing – Pediatric

• Safety and efficacy in pediatric patients not established

Monitoring

• Not required

*The International Society on Thrombosis and Haemostasis (ISTH) 2016 guidelines suggest avoiding NOACs in patients with BMI >40 kg/m2 or weight >120 kg due to lack of clinical data