Elective Reversal (reversal needed within days)

• Hold evening dose day prior.
• Hold for >72 hrs before neuraxial anesthesia.

Urgent Reversal (not bleeding, reversal needed within hours)

• Hold further doses
• Consider: 4-factor PCC/3-factor PCC + FFP, rVIIa

Urgent Reversal (bleeding, reversal needed immediately)

• HASHTI
• 4-factor PCC
• 3-factor PCC + FFP
• Consider rVIIa

* The use of aPCC (FEIBA⁷⁰) may be associated with a higher risk of thrombosis compared with nonactivated PCCs¹¹⁰.