Protamine Sulfate

Adverse Effects

Fast infusion can cause hypotension and bradycardia
Hemorrhage due to anticoagulant effect at high dose
Full reversal of heparin, 60-80% reversal of LMWH
Heparin rebound (protein-bound heparin dissociates slowly and binds to anti-thrombin III to produce an anticoagulant effect)

Abbreviation	Definition
AAA	Abdominal Aortic Aneurysm
ABCs	Airway, breathing and circulation
ABS	Acrylonitrile Butadiene Styrene
ACS	Acute Coronary Syndrome
ACT	Activated clotting tim
Anti-Xa	Anti factor Xa level; used for monitoring heparins
APLA	Antiphospholipid antibody syndrome
approx	Approximately
APTT	Activated partial thromboplastin time
ASA	Acetylsalicylic acid
AT3	Antithrombin 3
BID	Twice Daily
CABG	Coronary artery bypass grafting
CBC	Complete blood count
CDT	Catheter-directed Thrombolysis
CI	Continuous infusion
CMP	Comprehensive metabolic panel
COX	Cyclooxygenase
Cryo	Cryoprecipitate
DAT	Direct antiglobulin test
DDAVP	Desmopressin acetate
DIC	Disseminated intravascular coagulation
DVT	Deep venous thrombosis
EACA	Epsilon aminocaproic acid
F	Factor
FEIBA	Factor eight inhibitor bypassing activity
FFP	Fresh frozen plasma
FIX	Factor IX
Gm	Gram
HAV	Hepatitis A virus
Hb	Hemoglobin
HBV	Hepatitis B virus
HCV	Hepatitis C virus
HD	Hemodialysis
HIV	Human immunodeficiency virus
hrs	Hours
I.V.	Intravenous
ICU	Intensive care unit
INR	International normalized ratio
IPA	Inhibition of Platelet Aggregation
IU/kg	International units per kilogram of body weight
LFT	Liver function tests
LMWH	Low molecular weight heparin mcg
mcg	Microgram
mg	Milligram
MI	Myocardial infarction
min	Minutes
NOAC	Non Vitamin K Oral Anticoagulant
P.O.	Per os (oral)
PAI-1	Plasminogen activator inhibitor-1
PCC	Prothrombin Complex Concentration
PCI	Percutaneous Coronary Intervention
PE	Pulmonary embolism
PFA-100	Platelet function analyzer-100; in vitro bleeding time
PRN	As Needed
PT	Prothrombin time
Q	Every
QID	Four times daily
RES	Reticuloendothelial system
rt-PA	Recombinant tissue plasminogen activator
rVIIa	Recombinant factor VIIa (NovoSeven RT)
SC	Subcutaneous
STEMI	ST-Elevation Myocardial Infarction
TCT	Thrombin clotting time
TEG	Thromboelastogram
TPA	Tissue plasminogen activator
U/kg	Units/ kg
UFH	Unfractionated heparin
VKA	Vitamin K antagonists

Abbreviations